Checkpoint immunotherapy is a breakthrough in cancer treatment — and it may also promote HIV remission.
New studies add to the evidence that immune checkpoint inhibitors are safe and effective for people with HIV and cancer. What’s more, a growing body of research suggests that this type of immunotherapy could also play a role in a functional cure for HIV.
Checkpoint inhibitors, the most widely used type of immunotherapy, are a breakthrough in treatment for several types of cancer. These monoclonal antibodies interfere with receptors on immune cells that regulate immune response. For example, drugs that block PD-1 or its binding partner, PD-L1 — such as Keytruda (pembrolizumab) — can restore lost T-cell activity, while those that block CTLA-4 — such as Yervoy (ipilimumab) — promote T-cell multiplication.
Source : POZ
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