Enemas, suppositories, and inserts are acceptable for applying HIV-prevention medicine before anal sex

A clinical trial showed that most people who have receptive anal sex rated enemas, suppositories and rectal inserts as highly acceptable methods to use rectal microbicides, an experimental HIV-prevention strategy that does not yet have an effective formulation. The racially diverse and multinational participants tried all three methods, which were loaded with placebos, and reported how often they used them and how well they liked them. Of the three products, suppositories scored the lowest with the proportion of people who used them consistently and who rated them as highly acceptable at 66% and 74%, respectively. More than 70% of people consistently used enemas and inserts regularly, and more than 75% rated them both highly.

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