Randomized controlled clinical trials in San Francisco and France have found a significant decrease in the risk of key sexually transmitted infections (STIs) when doxycycline post-exposure prophylaxis (doxyPEP) is used shortly after sex. In these well-designed studies, the risk of developing syphilis was reduced by 73 per cent to 80 per cent among gay and bisexual men who have sex with men (gbMSM) and transgender women who have sex with men. DoxyPEP decreased the risk of infection with chlamydia, and in places where the bacteria that cause gonorrhea were susceptible to this drug, the risk of gonorrhea also decreased.
The overall reduction in STI risk, demonstrated by these studies, has led to increasing doxyPEP use among gbMSM, transgender women and other populations at risk for key STIs.
Source : CATIE
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