At CROI 2026, investigators presented preliminary data from the RIO trial suggesting that exposure to broadly neutralizing antibodies may alter viral rebound dynamics following treatment interruption in a subset of individuals living with HIV.
The findings do not represent a cure, nor do they support treatment interruption outside clinical trials. However, they provide early evidence that immune-based interventions might modulate post-treatment viral control.
The results presented reflect only part of the ongoing study, and several mechanistic analyses remain in progress.
The RIO trial evaluates two long-acting broadly neutralizing antibodies — 3BNC117-LS and 10-1074-LS — administered to individuals who initiated antiretroviral therapy early after infection and maintained sustained viral suppression.
Source : Life4me+
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