For years, HIV has been synonymous not only with chronic infection but also with the specter of accelerated immune aging — an assumption that long-term damage to the immune system was inevitable, even in the era of effective treatment. But new data presented at CROI 2026 suggest a far more hopeful narrative: in people living with HIV on decades of antiretroviral therapy, the immune system may be more resilient — and even more adaptable — than previously believed.
The research examined how sustained viral suppression over 25 to 30 years reshapes HIV-specific CD8⁺ T-cell responses, offering fresh insight into immune reconstitution and the long-term prospects for HIV remission.
Source : AJMC
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