aidsmap news story
The outcomes of lymphoma – one of the most common types of cancer in people with HIV – seem to be largely uninfluenced by viral suppression at the time of diagnosis. Although people with detectable viral load had lower CD4 counts and more advanced lymphoma when diagnosed, their chances of remission and survival were similar to those of people whose HIV was suppressed.
The higher rates of lymphoma, a cancer of the immune system, in people with HIV may be triggered by several mechanisms, including increased immune cell turnover, inflammation, immune suppression and direct virus interactions with the cells. Therefore, ongoing viral replication might be expected to contribute to lymphoma development and possibly worsened outcomes. However, the findings of Dr Teresa Aldámiz-Echevarria and colleagues, published in the journal HIV Medicine, suggest that once lymphoma has developed, its outcomes are mainly driven by immune status (including CD4 count), age and lymphoma type.
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Source : aidsmap
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