Gastroenterology Advisor: Tenofovir alafenamide linked to lower HCC risk than tenofovir disoproxil fumarate

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Gastroenterology Advisor news story

Tenofovir alafenamide reduces risk for hepatocellular carcinoma (HCC) by 71% relative to tenofovir disoproxil fumarate in antiviral-naïve chronic hepatitis B (CHB), according to study findings published in Journal of Gastroenterology and Hepatology.

The data support consideration of tenofovir alafenamide, especially in subgroups at heightened HCC risk. Prospective, long-term studies are warranted to validate these findings and elucidate mechanisms by which nucleos(t)ide analog choice may influence carcinogenesis in chronic hepatitis B.

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