Mass General Brigham news release
Chronic hepatitis B virus (HBV) infections can cause life-threatening liver disease. Before December 2025, the US Centers for Disease Control recommended universal vaccination at birth. In December 2025, the Advisory Committee on Immunization Practices (ACIP) recommended deferred vaccination when infants born of mothers without HBV are at least two months old. In January 2026, the CDC switched to recommending a “shared clinical decision-making” approach for infants born of mothers without HBV. Though these recommendations have been challenged by professional medical societies and public health agencies, their clinical impact on HBV is unclear.
In a new study, Mass General Brigham researchers used a model to simulate the impact of the new HBV vaccination recommendations on HBV infections and susceptibility. Compared with universal vaccination at birth, they estimated that delaying HBV vaccination until infants are two months old would increase the number of chronic HBV infections by around 19%, whereas a shared decision-making strategy would increase infections by around 83%. The results are published in Annals of Internal Medicine.
Read the full news release here.
Source : Mass General Brigham
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