A pair of immune-modulating drugs, budigalimab and trosunilimab, appeared to slow viral rebound in about a quarter of people with HIV who stopped antiretroviral therapy (ART), according to study results presented at CROI 2026. Some participants eventually saw their viral load rise with further follow-up, however, and development of this combination will not continue.
Based on presented results, “levels and durability of ART-free viral control are not sufficient to offer transformational benefits to people living with HIV and do not justify further development of budigalimab plus trosunilimab,” the researchers concluded. “These findings suggest that further studies of immune-mediated therapy with anti-PD1 agents may require approaches involving novel mechanisms.”
Source : aidsmap
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