Aicuris announced positive results from its phase 3 PRIOH-1 trial evaluating its investigational antiviral, pritelivir, in immunocompromised patients (including people living with HIV) with refractory herpes simplex virus (HSV) infections, with or without antiviral resistance. The findings represent a major advance for a patient population with few effective and well-tolerated treatment options.
The global, controlled, open-label study assessed the efficacy and safety of pritelivir, a first-in-class helicase-primase inhibitor, compared with investigator’s choice therapy (ICT). Current ICT options for refractory HSV — such as intravenous foscarnet, cidofovir, or topical imiquimod — are often limited by toxicity, resistance, and the need for prolonged intravenous administration in healthcare settings.
Source : Contagion Live
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