The latest TB research updates:
Praedicare Inc. announced it has been awarded a two-year $2.8 million grant by the Bill & Melinda Gates Foundation to evaluate novel TB drug regimens using Praedicare’s in vitro hollow fiber model of TB in identifying potential new drug regimens that shorten treatment times for the disease.
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The Xpert Ultra molecular test has a greater capacity than its predecessor (Xpert MTB/RIF) in detecting TB cases, either passively (i.e. people who attend the hospital with disease symptoms) or actively (searching for possible cases in the community among contacts of cases). This is the main conclusion of a study published in the European Respiratory Journal.
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The SARS-CoV-2 virus that causes COVID-19 may have the ability to reactivate dormant TB. In a novel study scientists reported in The American Journal of Pathology that infection with a specific coronavirus strain reactivated dormant Mycobacterium tuberculosis in mice. This knowledge may help to develop new vaccines for COVID-19 and avoid a potential global TB epidemic.
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Two new studies have cast unprecedented light on disease processes in TB, identifying key genetic changes that cause damage in the lungs and a drug treatment that could speed up recovery.
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In a paper published in eLife, researchers described a novel detection system, connected to the virulence factor that Mycobacterium tuberculosis uses to sense and counteract the human immune defense. The discovery represents a major advance in scientists’ understanding of how TB thrives in humans, and it gives drug developers a potential new target.
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