World Health Organization news release
The World Health Organization (WHO) has published Target regimen profiles for long-acting injectables for tuberculosis prevention and treatment. TB prevention and treatment still depend on daily oral regimens taken over months, and sustaining adherence over such periods is difficult for many people. Long-acting injectables (LAIs) could significantly lighten the burden for people taking TB medicines and the health system that delivers them. They have already changed the management of other conditions, most visibly HIV, and several LAI candidates for TB are now entering or approaching clinical development.
The target regimen profiles set out, early in development, what a new LAI regimen for TB preventive treatment or for the treatment of TB disease would have to achieve to be useful in practice. They are intended for the pharmaceutical industry, academia, research institutions, product development partners, TB-affected communities, civil society organizations and donors. For each characteristic they define a minimal requirement, which a product must meet to be worth pursuing, and an optimal requirement, the most desirable yet realistically achievable target.
Read the full news release here.
For more TB updates, check out the TB CAB Weekly Newsletter (Issue #29, 30 October 2026).
The newsletter is brought to you by the Global TB Community Advisory Board (TB CAB) with the support of Treatment Action Group (TAG) and the European AIDS Treatment Group (EATG). Subscribe to the newsletter here.
Source : World Health Organization
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