WHO releases new Target Product Profiles for TB screening tests

11 August 2025 | Geneva — The World Health Organization (WHO) has published today updated Target Product Profiles (TPPs) for tuberculosis (TB) screening tests. These TPPs define the most important characteristics and requirements to be considered in the development of new tests for systematic screening for TB and active TB case finding.

In 2014, WHO published its first TPPs for tests to improve the early detection of TB, with the intent to spur the development of novel tools that could detect more people with TB whose diagnosis would otherwise be missed or delayed. In the decade since the first TPPs were released, there have been significant advancements in screening technology, including portable digital radiographic equipment, alongside innovations driven by artificial intelligence (AI) including computer-aided detection software, which can provide automated interpretation of chest X-ray for TB screening. Despite these advances, important challenges remain in bringing screening to the scale needed to close the case detection gap and reduce the TB burden globally. Foremost among these challenges are the availability of screening tools with a low cost and high accuracy.

The 2025 TPPs provide technology-agnostic guidance encompassing all possible approaches used for screening. Three types of screening tools are defined, that may be effective in TB screening in different settings and situations. These updated TPPs were developed after in-depth discussion with global experts for options in novel TB screening tests, informed by modelling of the performance and costs of novel tests.

“The global community needs tools to screen and detect TB which are better and more accessible in hard-to-reach settings”, said Dr Tereza Kasaeva, Director of the WHO Department for HIV, Tuberculosis, Hepatitis, and Sexually Transmitted Infections. “The new WHO TPPs will inform manufacturers about the features that these new tests should have if they are to address the needs of the TB community and achieve the ambitious global commitments for TB detection and reduction of TB incidence and deaths.”

For more TB updates, check out the TB CAB Weekly Newsletter (Issue #26, 19 August 2025).

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