Post-exposure prophylaxis (PEP) has long been a critical strategy in preventing HIV after a potential exposure. In May 2025, the Centers for Disease Control and Prevention (CDC) released updated recommendations for non-occupational PEP (nPEP), reflecting advances in antiretroviral therapy and evolving optimal public health strategies. The guidelines seek to enhance the effectiveness, accessibility, and strategic deployment of nPEP after exposures to HIV through sexual contact, injection drug use, or other incidents that are not related to occupational exposure.
An article, published in Expert Review of Anti-infective Therapy, summarizes the key updates and implications for clinical practice.
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