In HIV management, weight change following a switch to integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) is 2-fold higher in women than in men over a 5-year period. These study results were published in Clinical Infectious Diseases.
Researchers conducted a study to determine the influence of patient sex on long-term changes in body weight among patients with HIV who switch to INSTI-based ART regimens. Data for this analysis were sourced from cohort studies published in the United States between 2007 and 2020. Eligible patients (N=3464) included those who switched to or added INSTIs to their current ART regimen (n=634), those who remained on non-INSTI-based regimens (n=1121), and those without HIV infection (n=1709). The researchers compared changes in body weight between all 3 groups after stratifying patients by sex. Linear regression mixed-effect models were constructed for statistical analysis.
Read the full story at Infectious Disease Advisor.
Source : Infectious Disease Advisor
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