This Q&A is about the RIO study and using immune-based treatments as part of HIV cure-related research.
In March 2025, the first results from the RIO study were presented at CROI.
The results showed that immune-based treatments called broadly neutralising antibodies (bNAbs) could keep viral load undetectable without HIV meds (ART).
RIO also showed that in some people bNAbs can also work like an HIV vaccine. Some people responded so well that they have not needed ART for over a year. These early results are exciting, but we need to see how long this response lasts.
We also need to understand why the bNAbs only worked for some people and not others.
Similar results were also reported in South African women in a study called FRESH.
Read a Q&A section about the RIO study and using immune-based treatments as part of HIV cure-related research, prepared by Simon Collins, HIV i-Base, here.
Simon Collins is a community representative on the RIO study.
Source : HIV i-Base
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