The cornerstone of HIV treatment may be losing some of its power: will dolutegravir resistance become a problem?

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A number of presentations at last week’s Conference on Retroviruses and Opportunistic Infections (CROI 2024) looked at whether HIV is starting to develop resistance to dolutegravir, one of the most widely used antiretrovirals in the world.

Guidelines in most parts of the world recommend dolutegravir (or its close cousin, bictegravir) as a component of most people’s first HIV treatment regimen. The World Health Organization recommends it for all populations, and if it wasn’t part of a person’s first-line HIV treatment, it will usually be part of their second-line regimen. The majority of low- and middle-income countries have now switched to a combination pill of tenofovir, lamivudine and dolutegravir (TLD), including South Africa, home of the world’s largest antiretroviral therapy programme.

Read the full story at Aidsmap.

 

Source : Aidsmap

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