Semaglutide reduces alcohol and cigarette use in a randomised phase 2 study

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GLP-1 receptor agonists are now first-line therapy in US guidelines for the management of type-2 diabetes and are approved at higher doses for weight loss.

One potential mechanism of action for the dramatic weight reductions involves blocking the reward pathway in the brain, as anecdotally people lose interest in eating. This is supported by some study participants reporting a similar lack of interest in other addictive behaviour, for example reducing alcohol use.

Read the full report by Simon Collins, HIV i-Base here.

 

Source : HIV i-Base

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