Researchers see dramatic drop in HIV-infected immune cells in patient after cancer treatment received

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Johns Hopkins Medicine press release

In a paper published in the Journal of Clinical Investigation (JCI), researchers at Johns Hopkins Medicine report they may have taken an early step toward a more practical HIV cure. The researchers focused on a patient undergoing cancer treatment and also living with HIV, who after receiving chemotherapy, had a significant reduction in the number of CD4+ T immune cells that contained an HIV provirus ― a key player in HIV’s ability to persist in the body.

The patient in the JCI study received two chemotherapeutic drugs for metastatic lung cancer: paclitaxel and carboplatin. “We suspect that the HIV-infected CD4+ T cells might have been highly susceptible to these drugs and were kept from proliferating in the patient,” says study co-senior author Joel Blankson, M.D., Ph.D., professor of medicine at the Johns Hopkins University School of Medicine. “Our experiment was designed to learn if that’s what really occurred.”

Read the full press release here.

 

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