Infectious Disease Advisor: Monthly islatravir shows comparable safety for HIV PrEP, lowers lymphocyte counts

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Infectious Disease Advisor news story

Among cisgender men and transgender women at increased risk for HIV-1 exposure, once-monthly oral islatravir demonstrates a safety profile similar to standard daily PrEP, while being associated with reductions in lymphocyte counts, according to study findings published in Clinical Infectious Diseases.

Investigators conducted a randomized, double-blind, phase 3 trial (IMPOWER-24) to assess the safety and tolerability of once-monthly oral islatravir compared with daily emtricitabine plus tenofovir disoproxil or tenofovir alafenamide for HIV prevention.

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