The potential to use reduced dosing was one of the controversial issues at IAS 2025 with conflicting conclusion from two late-breaker studies.
A systematic review and meta-analysis of eight studies using 5, 4 or 3 compared to 7 daily doses each week found this to be both safe and effective. This study was to look at a potential crisis response to sudden cuts in PEPFAR and USAID funding. Results were presented by Cassie Fairhead from the Royal Free Hospital in London.
Source : HIV i-Base
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