The term “inflammaging” captures a reality that clinicians caring for people with HIV increasingly recognize: Chronic inflammation and accelerated immune aging are reshaping the long-term health picture for their patients, even those with durable viral suppression. In an interview from the recent Conference on Retroviruses and Opportunistic Infections (CROI 2026), Irini Sereti, M.D., Ph.D., walks through the mechanisms driving this process — and makes the case for metabolism as a unifying therapeutic target.
Sereti is the chief of the HIV Pathogenesis Section in the Laboratory of Immunoregulation at the National Institute of Allergy and Infectious Diseases (NIAID). Her group studies inflammatory complications in people with HIV, including the role of inflammasomes, the microbiome, genetics, and immune senescence.
Source : TheBodyPro
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