[CROI 2026] Infectious Disease Advisor: Mpox vaccination reduces disease severity but immunity may wane after 2 years

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Infectious Disease Advisor news story

Although mpox vaccination reduces disease severity, protection appears to diminish after 2 years, indicating that recent immunization may be more effective, according to study results presented at CROI 2026.

While previous research suggests that mpox vaccination attenuates disease severity, these studies often lack adjustment for important variables such as age and health status. To help fill this knowledge gap, researchers examined the relationship between mpox vaccination and disease severity with adjustment for potential confounders. They also assessed temporal associations between vaccination date and mpox severity.

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View all Infectious Disease Advisor reports from CROI 2026


 

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