[CROI 2026] HIV i-Base: Islatravir PrEP didn’t protect against M184V mutation in macaque study

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  • Prevention
February 24, 2026
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HIV i-Base news story

Results from a macaque study showed that although implants that slow-released a low dose of islatravir protected animals against rectal exposure to wild-type SHIV, it failed to protect against SHIV with the M184V mutation.

This study is important because although islatravir is no longer being developed as PrEP, it is structurally very similar to the investigational NRTTI MK-8527 which is now entering phase 3 studies as a once-monthly oral formulation of PrEP.

Read the full news story here.

View all HIV i-Base reports from CROI 2026

 

Source : HIV i-Base

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