A second study presented at CROI 2026 reported on the studies that led to selecting the 11 mg dose of MK-8527 (the successor compound to islatravir) that will be used in a once-monthly oral formulation in phase 3 PrEP studies.
This was decided based on PK results using doses from 6 mg to 12 mg from five phase 1 studies and one phase 2 study.
Source : HIV i-Base
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