CROI 2022: Could antibodies be used for children with HIV instead of pills?

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In a study presented at this week’s Conference on Retroviruses and Opportunistic Infections (CROI 2022), a combination of two broadly neutralising antibodies (bNAbs) enabled almost half of a group of children born with HIV to maintain an undetectable viral load over a six-month period.

Dr Roger Shapiro of Harvard Medical School conducted the study in collaboration with research institutes in the US and Botswana.

The study was called ‘Tatelo’, which means ‘the next thing’ in Setswana. Shapiro said children may be an important group to treat with longer-lasting antibody-based therapies as adherence to, and the side effects of, oral antiretroviral therapy (ART) are often challenging. In addition, there is evidence that in some children treated very soon after birth, limiting the amount and diversity of proviral DNA that ends up in the ‘reservoir’ of quiescent cells could give them a better chance at controlling HIV, spontaneously or with novel medications, later in life.

Read the full story at Aidsmap.

 

All Aidsmap reports from CROI 2022.

 

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Source : Aidsmap

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