Better viral suppression with dolutegravir than other antiretrovirals in pregnancy, but not all guidelines recommend it

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Pregnant women taking dolutegravir were significantly more likely to have a fully suppressed viral load at the time of delivery compared to women taking atazanavir/ritonavir or raltegravir, researchers in the United States report in the New England Journal of Medicine.

The researchers say that their findings support the use of dolutegravir in preference to atazanavir/ritonavir or raltegravir during pregnancy, with darunavir/ritonavir as an alternative where dolutegravir use is not feasible.

Several clinical trials have shown that dolutegravir treatment leads to superior viral suppression at the time of delivery – which minimises the risk of vertical HIV transmission – compared to efavirenz or to atazanavir/ritonavir. However, current guidelines for the use of antiretrovirals during pregnancy vary, partly due to the date they were last revised.

Read the full story at Aidsmap.


Source : Aidsmap

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