ART pipeline 2025: exciting dual long-acting combinations and the challenge of generic dolutegravir

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The Glasgow 2024 conference included several important sessions on ART, including upcoming pipeline drugs and the issues of drug resistance with integrase inhibitors.

José Arribas, from La Paz Hospital, Madrid, presented an update on a wealth of drugs in development that have extended dosing options from oral weekly combinations to a range of compounds given by injection or infusion every 2, 3, 4 or 6 months.

The great potency of many new compounds and stronger resistance profiles mean that many combinations only involve two drugs. Nine studies at Glasgow included new data on these compounds.

One caution is that these combinations are nucleoside-sparing and therefore without HBV coverage.

Read the full report by Simon Collins, HIV i-Base here.


All HIV i-Base reports from HIV Glasgow 2024 can be accessed here.

 

Source : HIV i-Base

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