[Advocacy brief] TAG: Overcoming barriers to adopting the four-month regimen: A pathfinding mission to improve access to newer TB treatments

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TAG advocacy brief

Drug-sensitive TB treatment can be shortened from six to four months by replacing rifampicin with rifapentine and ethambutol with moxifloxacin. For people with TB, shortening the time on treatment by a third means less time away from work or school, a faster return to life without TB, and fewer healthcare visits and lower out-of-pocket costs along the way. The World Health Organization endorsed the four-month “HPMZ” (isoniazid, rifapentine, moxifloxacin, pyrazinamide) regimen in 2021, but its use remains limited.

Treatment Action Group (TAG) released an advocacy brief reviewing barriers to the adoption of the four-month regimen and how they might be addressed, and offering a narrative framework communities can use to advocate for the regimen in Global Fund Grant Cycle 8 and beyond.

Access the advocacy brief here.


For more TB updates, check out the TB CAB Weekly Newsletter (Issue #20, 17 July 2026).

The newsletter is brought to you by the Global TB Community Advisory Board (TB CAB) with the support of Treatment Action Group (TAG) and the European AIDS Treatment Group (EATG). Subscribe to the newsletter here.


 

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