Latest TB scientific highlights:
- Boston University School of Public Health: BCG vaccine prevents TB in young children, but not adults
Amidst longstanding debate on the effectiveness of the TB vaccine, bacille Calmette-Guérin (BCG), a new study suggested that the vaccine is protective against TB in children under 5, but adolescents and adults in high-burden countries may need additional protection to maintain immunity beyond childhood.
- Murdoch Children’s Research Institute: Immune boosting benefits of TB vaccine seen in infants more than a year after vaccination
A study, published in Science Advances, showed how the bacille Calmette-Guérin (BCG) vaccine, developed to prevent the risk of TB, can produce a ‘trained immunity response’ in infants lasting more than 14 months after the vaccine is administered.
- University of North Carolina Health Care: Scientists create long-acting injectable drug delivery system for TB
Researchers showed in vivo efficacy of a long-acting injectable formulation of the TB drug rifabutin. Published in Nature Communications, research in animal models showed the potential of delivering the TB drug with one injection that lasts at least four months, in lieu of the current standard treatment requiring constant adherence to a daily drug regimen.
- Medical Xpress: New antibiotic resistance genes identified in TB
A massive analysis of more than 10,000 different Mycobacterium tuberculosis bacteria isolates from 23 countries has revealed new genes associated with resistance to 13 first- and second-line new and repurposed antibiotics.
For more TB news, check out the latest edition of the TB Online Weekly Newsletter (#28, 11 August 2022).
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