Emory University news release
Emory University researchers have provided the first proof-of-concept in a nonhuman primate model for eliminating HIV-infected cells with venetoclax, a clinically approved medication for cancer. Venetoclax effectively targets and blocks Bcl-2, a protein that not only regulates whether cells live or die but also promotes the survival of cancer cells. Similarly, Bcl-2 is a culprit in sustaining HIV cell reservoirs. The research team determined venetoclax is also effective at reducing simian immunodeficiency virus (SIV) reservoir levels in vivo when given as part of a combination treatment for HIV.
The study results are reported in Nature Microbiology, and two clinical trials are under way to test venetoclax in people living with HIV.
Read the full news release here.
Source : EurekAlert!
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