UC Davis School of Medicine: Probiotic-derived bioactive metabolite reverses gut dysfunction and boosts HIV treatment response

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Combining 10-HSA with standard antiretroviral therapy improved viral suppression and helped rebuild gut immune defenses in animal models of AIDS.

UC Davis School of Medicine news release

Scientists have identified a naturally occurring metabolite that repairs gut damage caused by HIV infection and significantly improves the effectiveness of antiretroviral therapy in the nonhuman primate model of HIV/AIDS.

The biotherapeutic metabolite, 10-hydroxystearic acid (10-HSA), is produced by the beneficial gut bacterium Lactiplantibacillus plantarum. L. plantarum is a common lactic acid bacterium found in many over-the-counter probiotics and fermented foods. It also occurs naturally in the human gut.

Read the full news release here.

 

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