UNC School of Medicine: Scoping review highlights wide variation in how PrEP “persistence” is defined, complicating HIV prevention policy and research

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UNC School of Medicine news release

A new comprehensive scoping review finds that definitions of “persistence” in HIV PrEP research vary widely across studies, making it difficult to compare outcomes, evaluate interventions, and inform public health decision‑making.

If taken consistently and as prescribed, PrEP is highly effective in preventing HIV. However, staying on PrEP through periods of HIV vulnerability is critical to achieving its full prevention impact. This concept of continuing PrEP is frequently described as “persistence.” The new review shows persistence outcomes are rarely defined consistently across the scientific literature, variation that could have substantial implications for how PrEP programs are evaluated and scaled.

Read the full news release here.

 

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