WHO issues first recommendation on doxyPEP to help prevent STIs

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World Health Organization press release

18 May 2026 | Geneva — The World Health Organization (WHO) has issued its first recommendation on the use of doxycycline post-exposure prophylaxis (PEP) – commonly referred to as doxyPEP – for the prevention of bacterial sexually transmitted infections (STIs) among men who have sex with men and transgender women.

The new recommendation, issued following a WHO guideline development process, reflects growing evidence that doxycycline taken after sexual exposure can reduce the risk of syphilis and chlamydia, and may also reduce gonorrhoea in some settings. These infections continue to rise in many regions worldwide, disproportionately affecting key populations.

Read the full press release here.

Access the recommendation here.

 

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