Caring Cross announced early clinical data from a first-in-human Phase I/IIa trial of a novel CAR-T cell strategy in people living with HIV.
The findings provide preliminary data suggesting that anti-HIV CAR-T cell therapy could lead to durable viral control, particularly in those who started HIV treatment early in the course of their infection.
The Phase I/IIa clinical trial is evaluating the safety and preliminary efficacy of an anti-HIV duoCAR-T therapy in ART-suppressed individuals. The therapy uses a participant’s own T cells, which are genetically engineered using Caring Cross’s proprietary duoCAR technology and reinfused. To date, nine participants have received therapy in this first-in-human dose-escalation study.
Source : Caring Cross
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