ViiV Healthcare announced data from its phase 1 study of long-acting formulations of VH184, the first, third-generation integrase strand transfer inhibitor (INSTI) in development for HIV. Results show a single-dose injection could maintain drug levels for up to six months. In-vitro data from a separate study demonstrate improved potency and an enhanced resistance profile versus bictegravir in resistant HIV strains.
Additional data from ViiV Healthcare’s long-acting pipeline presented at CROI 2026 show VH499, an investigational capsid inhibitor, was generally well tolerated and support the potential for ultra long-acting twice-yearly dosing.
Source : ViiV Healthcare
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