[CROI 2026] Contagion Live: Switching to doravirine/islatravir maintains viral suppression through 96 weeks (MK-8591A-051 & MK-8591A-052)

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Switching to doravirine/islatravir maintains viral suppression through 96 weeks (MK-8591A-051 study)

New 96-week data from the open-label, phase 3 MK-8591A-051 study demonstrate that switching to the fixed-dose combination of doravirine and islatravir (DOR/ISL, 100/0.25 mg) continues to support durable viral suppression and long-term tolerability in adults with HIV who were previously virologically suppressed on oral antiretroviral therapy.

Doravirine/islatravir combination maintains virologic suppression through 96 weeks (MK-8591A-052 study)

The 96-week data from the double-blind, phase 3 MK8591A-052 trial show that switching to doravirine/islatravir maintained durable virologic suppression with efficacy and safety comparable to continuing bictegravir/emtricitabine/tenofovir alafenamide.


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