A compound called CJF-III modifies the protein “shell” of the virus and allows for a better immune response to the virus.
An international team led by two Université de Montréal researchers has unveiled how a molecule capable of opening the “shell” of HIV improves the elimination of infected cells.
In a study, published in Nature Communications, researchers demonstrated how a new CD4-mimetic compound, CJF-III-288, modifies the HIV envelope protein structure to allow for a better immune response.
Similar to the CD4 protein that allows HIV to infect cells, the compound binds to the virus, making it detectable and therefore vulnerable to the immune system.
This new approach could be a significant step towards reducing viral reservoirs that prevent people living with HIV to get rid of the virus.
Read the full news story here.
Source : Université de Montréal
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