A study published in Nature Communications makes a significant technical breakthrough. The team developed a method of delivering mRNA into resting CD4 T cells using a specially designed lipid nanoparticle termed LNP X. LNPs were previously used to help deliver COVID-19 mRNA vaccines. The researchers showed that under laboratory conditions, LNP X efficiently delivers the mRNA encoding candidate cure tools—such as HIV Tat mRNA and HIV long terminal repeat CRISPR activation (CRISPRa)—directly into resting CD4 cells.
Read the full expert analysis from Benjamin Young, MD, PhD and what makes this particular cure study stand out at TheBodyPro.
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amfAR: Researchers target and awaken dormant HIV in groundbreaking advance – Prof. Sharon Lewin explains the research findings (watch a video)
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