Analysis of tissue samples from six people with HIV who passed away due to terminal illness revealed varying concentrations of dolutegravir in different body sites and organs. Unsurprisingly, drug concentrations in the brain and the spinal cord were lower than in other body sites, but concentrations across different parts of the brain were evenly distributed. In contrast, the intestines and the spleen – where a large portion of the immune system resides – were found to have high drug concentrations. Dr Micol Ferrara and colleagues shared these findings in a poster at the Conference on Retroviruses and Opportunistic Infections (CROI 2024) held in Denver this week.
Read the full story at Aidsmap.
Source : Aidsmap
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