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Inflammation persists despite very early HIV treatment

Biomarkers of inflammation increase during acute HIV infection and remain elevated despite early suppressive antiretroviral therapy, according to a study presented at CROI 2015, in Seattle, Washington. The study, presented by Netanya Sandler Utay, M.D., followed 78 acutely HIV-infected individuals and 109 HIV-negative individuals from Thailand, from diagnosis or enrollment to 96...


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Impact of specific antiretroviral drugs on non-AIDS mortality

LPV, ATV, NVP, but not EFV, tied to higher non-AIDS death rate in D:A:D Analysis of the D:A:D cohort linked cumulative use of lopinavir, atazanavir, or nevirapine to small but significant increases in the non-AIDS death rate [1]. The same analysis tied recent efavirenz exposure to about a 15% lower non-AIDS death rate. D:A:D is the large ongoing study of...


Source Source: NATAP

Natco Pharma ties up with Gilead on hepatitis C drugs

Natco Pharma Ltd said on Monday it has agreed a deal with Gilead Sciences Inc to supply generic copies of the U.S. drugmaker's chronic hepatitis C medicines, including $1,000-a-pill drug Sovaldi, in 91 developing nations. Natco, a mid-sized player in India's crowded pharmaceutical industry, is the latest generic drugmaker to team up with Gilead on Sovaldi, having...


Source Source: REUTERS

Dynavax announces second independent DSMB recommendation to continue Phase 3 study of HEPLISAV-B(TM)

BERKELEY, CA -- 02/03/15 -- Dynavax Technologies Corporation (NASDAQ: DVAX) today announced that the independent Data and Safety Monitoring Board (DSMB) charged with periodically reviewing safety data from the ongoing phase 3 clinical trial of HEPLISAV-B, its investigational adult hepatitis B vaccine, has completed its second prespecified review and has recommended that the study continue...


Roche launches next-generation viral load assay for HBV in markets accepting the CE mark

cobas HBV assay offers unparalleled performance on the cobas 6800/8800 Systems Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today (March 2) the commercial availability of the cobas® HBV quantitative nucleic acid test for use on the cobas® 6800/8800 Systems—adding to the viral load monitoring portfolio on the newest molecular diagnostic platforms from Roche. The new...


Source Source: Roche