EATG » CROI 2018: Once-daily tenofovir alafenamide appears sufficient when dosed with rifampicin

CROI 2018: Once-daily tenofovir alafenamide appears sufficient when dosed with rifampicin

Plasma concentrations of tenofovir alafenamide AUC were decreased by 55% and intracellular tenofovir-diphosphate concentrations by 36% when given with rifampicin. But intracellular concentrations were still 76% higher than those with standard dose tenofovir disoproxil fumarate.

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Source:
HIV i-Base
News categories: Tuberculosis, CROI 2018