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Vaccines

Fresh approach to TB vaccine offers better protection

New vaccine completely protected 41 percent of nonhuman primates; standard vaccine protected none A unique platform that resulted in a promising HIV vaccine has also led to a new, highly…

Investigation questions transparency for failed TB vaccine

The BMJ inquiry finds that researchers presented only select results from animal experiments when applying for funding and approval for human trials. Oxford University scientists developing the MVA85A vaccine, intended…

Hepatitis A vaccines effective in high-risk populations during outbreak

Two-dose hepatitis A vaccination was an effective preventive measure among HIV-positive individuals, including a high study population of men who have sex with men, during an ongoing outbreak of acute…

Overcoming difficulties developing an HIV vaccine

The development of a vaccine that protects against HIV infections has proven extraordinarily difficult. One of the reasons is that naïve precursor B cells that can give rise to mature…

VBI Vaccines announces initiation of Phase 3 clinical program for Sci-B-Vac® hepatitis B vaccine

Patient dosing commenced on December 18, 2017 4,800 subjects across two Phase 3 studies: PROTECT and CONSTANT 15-month program – headline data expected Q2 2019 December 19, 2017: VBI Vaccines…

HIV vax trial teaches lessons

Placebo control still has important place in clinical research Even a failed clinical trial can have valuable lessons. That's the message investigators are taking from a randomized, double blind trial…

HIV vaccine fails to suppress viral load, affect reservoir

An experimental therapeutic HIV vaccine regimen did not suppress the virus in patients whose ART was paused in a study testing the vaccine’s safety and efficacy, according to researchers. The…

Johnson & Johnson and partners announce first efficacy study for investigational mosaic HIV-1 preventive vaccine

On the eve of World AIDS Day, Bill & Melinda Gates Foundation and National Institutes of Health join forces with Johnson & Johnson to advance a potential “global vaccine” New…

Four big insights into HIV/AIDS that provide hope of finding a vaccine

HIV remains one of the continent’s most intractable health challenges. Tremendous progress is being made to understand the virus, the immune mechanisms that contribute to its control and for new…

Insights from infants could inform HIV vaccine design

Dr. Julie Overbaugh mines decades-old samples to find new clues to effective immune responses to HIV When it comes to building an HIV vaccine, important lessons can come from unexpected…

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