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Scientific research

CRISPR-Cas9: a world first?

On Nov 26, when the world heard the claims that the first genetically edited children had been born, the reaction was one of deep and profound shock. He Jiankui announced…

Infectivity of different HIV-1 strains may depend on which cell receptors they target

Distinct HIV-1 strains may differ in the nature of the CCR5 molecules to which they bind, affecting which cells they can infect and their ability to enter cells, according to…

Genetic relic of the ‘black death’ may offer clues in treating liver disease

CINCINNATI--A gene mutation that is believed to have safeguarded some people in 14th century Europe from the bubonic plague today may be protecting HIV patients co-infected with hepatitis C from…

Eliminating the latent reservoir of HIV

A new study suggests that a genetic switch that causes latent HIV inside cells to begin to replicate can be manipulated to completely eradicate the virus from the human body.…

Investigators discover compounds that block reactivation of latent HIV-1

Washington, DC - December 3, 2018 - A team of investigators from the University of Pittsburgh has identified compounds that block the reactivation of latent HIV-1 in a human cell…

Focus on resistance to HIV offers insight into how to fight the virus

Of the 40 million people around the world infected with HIV, less than one per cent have immune systems strong enough to suppress the virus for extended periods of time.…

Therapeutic vaccines offer hope for a functional cure for HIV

EU-funded researchers are leading efforts to develop a functional cure for HIV using innovative therapeutic vaccines to halt the progression of the devastating virus, increase the availability and affordability of…

HIV in liver cells found to be inactive, narrowing potential treatment targets

New study reveals that the largest population of human tissue macrophages, liver macrophages, do not contain infectious forms of HIV In a proof-of-principle study, researchers at Johns Hopkins revealed that…

Treatment Action Group statement on the reported birth of twins with edited CCR5 genes

New York, November 26, 2018 – Treatment Action Group (TAG) decries the claimed use of CRISPR technology to edit genes for the HIV co-receptor CCR5 in human embryos for implantation.…

Vir Biotechnology and Alnylam Pharmaceuticals initiate Phase 1/2 study of VIR-2218

-- Novel investigational RNAi therapeutic for the treatment of chronic hepatitis B virus (HBV) infection -- Subject dosing commenced SAN FRANCISCO, Calif. and CAMBRIDGE, Mass. – November 26, 2018 -…

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