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Pediatrics

Sofosbuvir/ledipasvir cures most young children with hepatitis C

Almost all young children ages 3 to 6 years with chronic hepatitis C achieved sustained virological response after 12 weeks of treatment using sofosbuvir/ledipasvir oral granules, according to findings presented…

In utero HIV infection sharply increases cytomegalovirus risk for newborns

Nearly 1 in 4 infants who acquire HIV infection in the womb will also contract congenital cytomegalovirus (CMV), according to new research. Kristina Adachi, MD, the study’s lead author and…

Jury still out on neural tube defects from dolutegravir

GLASGOW — Ever since four infants with neural tube defects were born to women in Botswana who were using dolutegravir at conception, researchers and surveillance experts have been scrambling to…

Dolutegravir use during pregnancy: What are the risks?

In May 2018, the US Food and Drug Administration (FDA) issued a warning that serious neural tube birth defects (NTDs) had been reported in women treated with dolutegravir (DTG) during…

Viral suppression in children on ART identified via quantitative HIV antibody levels

For children receiving antiretroviral therapy (ART), HIV-1-specific antibody levels can be useful markers for identifying those with viral suppression or low residual cell-associated HIV-1 DNA levels, according to research published…

HIV-positive infants are at high risk for acquiring congenital cytomegalovirus infection

FINDINGS Infants born to HIV-positive mothers had high rates of congenital cytomegalovirus, or CMV. Infants who also were infected before birth by the virus that causes AIDS were especially prone…

Efavirenz, but not dolutegravir, linked to neurological problems in children

Children born to HIV-positive women who take efavirenz (Sustiva or Stocrin, also a component of Atripla) during pregnancy are at greater risk of developing neurological disorders, some of which may…

Efavirenz in pregnancy tied to neurologic risk in children

SAN FRANCISCO — Children were 60% more likely to be diagnosed with a neurologic condition, such as microcephaly, seizures, or eye abnormalities, when the antiretroviral regimen their mothers were taking…

Cardiac changes linked with specific ARVs in perinatally acquired HIV

Individual antiretroviral medications have been linked with changes in cardiac structure in youths with perinatally acquired HIV, according to a study recently published in AIDS. Although combinations of antiretroviral medications have…

Developmental problems of children born to women with HIV linked to substance use and HIV, not antiretrovirals

Pre-term births and developmental problems in children born to mothers with HIV are associated with HIV infection, substance use and smoking, Canadian researchers have reported in the journal AIDS. They…

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