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Immune response

How the border guards fail in HIV infection

The barrier between the gut and the bloodstream is severely damaged in the first few weeks of infection by HIV-1 virus. This can allow whole microbes in the intestine, as…

Antibody combination puts HIV on the ropes

Without antiretroviral drug treatment, the majority of people infected with HIV ultimately develop AIDS, as the virus changes and evolves beyond the body’s ability to control it. But a small…

New and touted HIV bNAb: Big deal or news blip?

Fervid research has uncovered dozens of antibodies that shield cells from HIV. These broadly neutralizing antibodies (bNAbs) protect monkeys from SHIV, the simian-HIV hybrid. Thousand-person human trials are already dripping…

Antibody breakthroughs give new hope for HIV treatment

Researchers in two new studies say they can leverage the body’s own antibodies to fight the virus that causes AIDS. In the field of HIV research, antibodies continue to be…

New broad-spectrum antiviral protein can inhibit HIV, other pathogens in some primates

University of Colorado Boulder researchers have discovered that a protein-coding gene called Schlafen11 (SLFN11) may induce a broad-spectrum cellular response against infection by viruses including HIV-1. The new research, which…

HIV treatment might boost susceptibility to syphilis, say researchers

The antiretroviral drugs used to treat HIV infection might inadvertently be boosting gay/bisexual men's susceptibility to the bacteria responsible for syphilis, Treponema pallidum, conclude researchers in the journal Sexually Transmitted…

Successful antibody trial in HIV-infected individuals

A research team led by investigators of the Rockefeller University in New York and Prof Florian Klein, University Hospital Cologne and German Center for Infection Research (DZIF), has tested a…

New research shows abnormal immune activation even in very early HIV infection

Even in very early (acute) HIV infection—before fourth generation HIV test assays are able to detect an HIV infection—immune activation and inflammatory processes may already be occurring, new research shows.…

Researchers find new therapeutic target against chronic viral infections

There are a number of things that can impact our immune system’s ability to eliminate a virus; the expression levels of particular proteins—specifically interferon proteins—is one of them. In the…

Protein that activates immune response harms body’s ability to fight HIV

UCLA-led researchers suggest that blocking type I interferon may help combat the virus that causes AIDS In findings they call counterintuitive, a team of UCLA-led researchers suggests that blocking a…