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Immune response

HIV reservoirs: Does the virus hide in the brain?

Treatment advances over the last several decades have dramatically extended the lifespan of patients with human immunodeficiency virus (HIV). However, a continuing problem in HIV treatment is the ability of…

Dendritic cells “divide and conquer” to elude viral infection while promoting immunity

A research team led by Jackson Laboratory (JAX) Professor Karolina Palucka, M.D., Ph.D., in collaboration with a research team at Institut Curie in France led by Dr. Nicolas Manel, have…

Pathway to ‘rejuvenating’ immune cells to fight cancers and infections

A new discovery of the mechanism of T cell exhaustion will lead to treatments to enhance immunotherapies against cancers and such viruses as HIV. St. Jude Children's Research Hospital immunologists…

Ancient retrovirus embedded in the human genome helps fight HIV-1 infection

A human endogenous retrovirus family, HERV-K, interferes with the replication and infectivity of HIV-1, new research concludes. Throughout our evolution, viruses have continually infected humans just as they do today.…

HIV superinfection is associated with specific HLA types

A study of factors associated with HIV superinfection was recently published from a prospective study of HIV positive gay men. While superinfection has been associated with increased disease progression, specific…

Natural history of elite controllers

A small subset of HIV positive people, referred to as elite controllers, are able to spontaneously control HIV infection to below 50 copies/mL without ART. Although genetic studies have identified…

Rising CD4+T cell counts after chemotherapy may contribute to HIV reservoir in patients with cancer

The increase of HIV–infected cytomegalovirus and Epstein-Barr specific CD4+T cells that occurs after patients with HIV complete chemotherapy may contribute to the HIV DNA reservoir, study data showed. “Systemic cytoreductive…

Interleukin-2 as an adjunct to antiretroviral therapy for HIV-positive adults

A study published in Cochrane Library assessed the effects of interleukin-2 as an adjunct to antiretroviral therapy for HIV-positive adults. HIV continues to be a leading cause of morbidity and…

Researcher to study antibodies in long-term nonprogression of HIV

Mark D. Hicar, MD, PhD, assistant professor of pediatrics, has been awarded a five-year, $1.9 million grant from the National Institute of Allergy and Infectious Diseases to investigate why some…

T-cell signaling process central to immune response

Scientists obtain first glimpse of the molecular mechanism by which recognition of an antigen by the T cell receptor triggers the first steps leading to an immune response The immune…

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