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Immune response

Research helps explain how vedolizumab antibody therapy leads to sustained viral remission

HIV and its monkey cousin SIV can carry the alpha-4 beta-7 integrin receptor in their outer envelope, which helps the virus enter gut cells during early infection, according to research…

Penn Medicine AIDS researcher receives $16.3 million from National Institutes of Health to accelerate HIV vaccine development

Research aims to overcome difficulties in inducing HIV neutralizing antibodies PHILADELPHIA— Building on earlier work in designing  chimeric human-simian immunodeficiency viruses  (SHIVs) that serve as a model of HIV infection…

Researchers map pathways to protective antibodies for an HIV vaccine

The findings advance progress toward HIV vaccine design DURHAM, N.C., March 15, 2017 – A Duke Health-led research team has described both the pathway of HIV protective antibody development and a…

Monkeys suppress HIV-like virus for extended period after dual-antibody treatment

Giving monkeys two powerful anti-HIV antibodies immediately after infection with an HIV-like virus enabled the immune systems of some of the animals to control the virus long after the antibodies…

Hepatitis C virus exposed to attack

Burnet Institute researchers have re-engineered the major protein of hepatitis C virus (HCV) to expose the virus more effectively to attack by the human immune system, an important step towards…

Powerful RNA-based technology could help shape the future of therapeutic antibodies

Pre-clinical study from Penn demonstrates protection against HIV PHILADELPHIA—Using antibodies to treat disease has been one of the great success stories of early 21st-century medicine. Already five of the ten…

Research could lead to better vaccines and new antivirals

Study identifies immune checkpoint as potential target to strengthen the innate immune response La Jolla, Calif., Feb. 27, 2016 -- Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have…

CROI 2017: Really Rapid Review

The Conference on Retroviruses and Opportunistic Infections (CROI) returned to Seattle this past week for its 24th meeting. It's the 4th time CROI has been held in Seattle, an excellent…

Monoclonal antibodies show promise for HIV-positive people with limited treatment options

A pair of long-acting monoclonal antibodies that prevent HIV from entering human cells – ibalizumab and PRO 140 – may offer new treatment options for people with highly resistant virus…

Understanding how HIV evades the immune system

Monash University and Cardiff University (UK) researchers have come a step further in understanding how the human immunodeficiency virus (HIV) evades the immune system. Declared a pandemic in 1987 by…

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