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Immune response

Baseline CD4 count biggest factor in long-term immune system improvements after starting HIV therapy

Pre-treatment CD4 cell count is the most important factor in immune recovery following the initiation of combination antiretroviral therapy (cART), according to the results of a large observation study published…

Age and T-cell markers not linked in HIV patients

Older age and HIV status independently affect an individual’s immune system. Yet, there is no evidence that HIV infection and advancing age together accelerate changes in age-related T-cell markers, according…

Immune cells turn back time to achieve memory

Memory T cells' genes poised to respond years after infection/vaccination Memory T cells earn their name by embodying the memory of the immune system -- they help the body remember…

Anti-aging protein could be targeted to rejuvenate immune cells

New study explains what happens when the immune system ages San Francisco, CA, November 30, 2017—Anti-aging proteins have long been shown to protect against age-related diseases, such as cancer, neurodegeneration,…

Preventing HIV at the initial stages of infection

In a project funded by the Austrian Science Fund FWF, Doris Wilflingseder investigates the initial stages of HIV infection, a period when the immune system might still stop the virus.…

Four big insights into HIV/AIDS that provide hope of finding a vaccine

HIV remains one of the continent’s most intractable health challenges. Tremendous progress is being made to understand the virus, the immune mechanisms that contribute to its control and for new…

Insights from infants could inform HIV vaccine design

Dr. Julie Overbaugh mines decades-old samples to find new clues to effective immune responses to HIV When it comes to building an HIV vaccine, important lessons can come from unexpected…

New findings to help HIV scientists establish ‘template’ for potent antibodies

Natural-infection studies in Africa and India continue to inform HIV vaccine design New data published today in Immunity further illuminate how some human beings generate powerful, HIV-blocking antibodies. Led by…

Effects of the anti-inflammatory antibody canakinumab on heart disease and cancer: implications for HIV?

Inflammation is increasingly recognized as an immunological double-edged sword: it contributes importantly to the response to infection, but can also cause serious collateral damage to the body—particularly when persistent—and has…

Immune response to HIV linked to cancer mutations

University of Saskatchewan researchers have found the onset of breast, lung and other cancers may be connected to malfunctions of the immune system as it combats specific viruses such as…