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Immune response

Rising CD4+T cell counts after chemotherapy may contribute to HIV reservoir in patients with cancer

The increase of HIV–infected cytomegalovirus and Epstein-Barr specific CD4+T cells that occurs after patients with HIV complete chemotherapy may contribute to the HIV DNA reservoir, study data showed. “Systemic cytoreductive…

Interleukin-2 as an adjunct to antiretroviral therapy for HIV-positive adults

A study published in Cochrane Library assessed the effects of interleukin-2 as an adjunct to antiretroviral therapy for HIV-positive adults. HIV continues to be a leading cause of morbidity and…

Researcher to study antibodies in long-term nonprogression of HIV

Mark D. Hicar, MD, PhD, assistant professor of pediatrics, has been awarded a five-year, $1.9 million grant from the National Institute of Allergy and Infectious Diseases to investigate why some…

T-cell signaling process central to immune response

Scientists obtain first glimpse of the molecular mechanism by which recognition of an antigen by the T cell receptor triggers the first steps leading to an immune response The immune…

No link found between HIV levels and immune activation during antiretroviral treatment

Pre-treatment immune events may result in elevated immune system activation during treatment Despite successful treatment, people receiving antiretroviral drugs continue to have small amounts of human immunodeficiency virus (HIV) in…

Defective HIV proviruses hinder immune system response and cure

Mutant forms of HIV complicate disease monitoring and distract the immune system from the functional virus Researchers at Johns Hopkins and George Washington universities report new evidence that proteins created…

Researchers examine the relationship between drug injection risk behaviors and immune activation

Harm reduction efforts should include treatment of HCV infection and encourage injection cessation or reduction in frequency to reduce immune activation and enhance related health benefits. The use of heroin…

Grant to evaluate HIV immunotherapy PENNVAX®-GP’s ability to induce HIV remission

Inovio and collaborators receive NIH grant to evaluate HIV immunotherapy PENNVAX®-GP’s ability to induce remission of HIV infection and end lifetime of drug therapy Grant will fund therapeutic clinical studies…

Research helps explain how vedolizumab antibody therapy leads to sustained viral remission

HIV and its monkey cousin SIV can carry the alpha-4 beta-7 integrin receptor in their outer envelope, which helps the virus enter gut cells during early infection, according to research…

Penn Medicine AIDS researcher receives $16.3 million from National Institutes of Health to accelerate HIV vaccine development

Research aims to overcome difficulties in inducing HIV neutralizing antibodies PHILADELPHIA— Building on earlier work in designing  chimeric human-simian immunodeficiency viruses  (SHIVs) that serve as a model of HIV infection…