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Immune response

NIH-supported scientists elicit broadly neutralizing antibodies to HIV in calves

Unique structure of bovine bNAbs may inform HIV vaccine, therapeutics design. Scientists supported by the National Institutes of Health have achieved a significant step forward, eliciting broadly neutralizing antibodies (bNAbs)…

Apply now! STEPS – Cure Workshop at the EACS Conference in Milan

If you are planning to attend the EACS meeting in Milan, Italy (October 25-27, 2017), you are invited to apply to attend the fourth community meeting on HIV cure, therapeutic…

Immune system may keep body from neutralizing HIV-1 virus

Findings could help develop a vaccine for the virus that causes AIDS AURORA, Colo. (June 11, 2017) - Researchers at the University of Colorado Anschutz Medical Campus have discovered that…

HIV reservoirs: Does the virus hide in the brain?

Treatment advances over the last several decades have dramatically extended the lifespan of patients with human immunodeficiency virus (HIV). However, a continuing problem in HIV treatment is the ability of…

Dendritic cells “divide and conquer” to elude viral infection while promoting immunity

A research team led by Jackson Laboratory (JAX) Professor Karolina Palucka, M.D., Ph.D., in collaboration with a research team at Institut Curie in France led by Dr. Nicolas Manel, have…

Pathway to ‘rejuvenating’ immune cells to fight cancers and infections

A new discovery of the mechanism of T cell exhaustion will lead to treatments to enhance immunotherapies against cancers and such viruses as HIV. St. Jude Children's Research Hospital immunologists…

Ancient retrovirus embedded in the human genome helps fight HIV-1 infection

A human endogenous retrovirus family, HERV-K, interferes with the replication and infectivity of HIV-1, new research concludes. Throughout our evolution, viruses have continually infected humans just as they do today.…

HIV superinfection is associated with specific HLA types

A study of factors associated with HIV superinfection was recently published from a prospective study of HIV positive gay men. While superinfection has been associated with increased disease progression, specific…

Natural history of elite controllers

A small subset of HIV positive people, referred to as elite controllers, are able to spontaneously control HIV infection to below 50 copies/mL without ART. Although genetic studies have identified…

Rising CD4+T cell counts after chemotherapy may contribute to HIV reservoir in patients with cancer

The increase of HIV–infected cytomegalovirus and Epstein-Barr specific CD4+T cells that occurs after patients with HIV complete chemotherapy may contribute to the HIV DNA reservoir, study data showed. “Systemic cytoreductive…