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Immune response

Four big insights into HIV/AIDS that provide hope of finding a vaccine

HIV remains one of the continent’s most intractable health challenges. Tremendous progress is being made to understand the virus, the immune mechanisms that contribute to its control and for new…

Insights from infants could inform HIV vaccine design

Dr. Julie Overbaugh mines decades-old samples to find new clues to effective immune responses to HIV When it comes to building an HIV vaccine, important lessons can come from unexpected…

New findings to help HIV scientists establish ‘template’ for potent antibodies

Natural-infection studies in Africa and India continue to inform HIV vaccine design New data published today in Immunity further illuminate how some human beings generate powerful, HIV-blocking antibodies. Led by…

Effects of the anti-inflammatory antibody canakinumab on heart disease and cancer: implications for HIV?

Inflammation is increasingly recognized as an immunological double-edged sword: it contributes importantly to the response to infection, but can also cause serious collateral damage to the body—particularly when persistent—and has…

Immune response to HIV linked to cancer mutations

University of Saskatchewan researchers have found the onset of breast, lung and other cancers may be connected to malfunctions of the immune system as it combats specific viruses such as…

World first: scientists find where HIV ‘hides’ to evade detection by the immune system

In a decades-long game of hide and seek, scientists from Sydney's Westmead Institute for Medical Research have confirmed for the very first time the specific immune memory T-cells where infectious…

Long-acting monoclonal antibody effective against multidrug-resistant HIV

Ibalizumab, a long-acting monoclonal antibody that prevents HIV from entering cells, maintained viral suppression for a year in people with highly resistant HIV and limited treatment options, according to a…

Three-in-one antibody protects monkeys from HIV-like virus

NIH and Sanofi scientists prepare to test antibody in people. A three-pronged antibody made in the laboratory protected monkeys from infection with two strains of SHIV, a monkey form of…

Five-drug early HIV treatment does not correct inflammation or immune deficits

Starting five-drug antiretroviral therapy (ART) in the first months of infection did not quell HIV-associated inflammation in a 22-man randomized comparison with standard ART. Intensified ART had little impact on…

STEPS IV Cure Workshop in Milan on 24/10/2017

If you are planning to attend the EACS meeting in Milan, Italy (October 25-27), you are invited to apply to the fourth community meeting focused on HIV cure, therapeutic vaccines…